There is a launch of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to decrease afferent discomfort transmission and deliver analgesia. As a result, medicines like clonidine that focus on alpha-two receptors can affect the transmission of pain. Applies to clonidine: oral https://www.proleviate.com/post/the-new-pain-killer-conolidine